Electroacupuncture reduces cold stress-induced pain through microglial inactivation and transient receptor potential V1 in mice

Abstract Background The treatment, and efficacy thereof, is considered to be inadequate with specificity alleviation of Fibromyalgia its associated pain. patients suffer from chronic persistent widespread pain generalized tenderness. Transient receptor potential V1 (TRPV1), which reported as a Ca 2+ permeable ion channel that can activated by inflammation, involved in the development fibromyalgia Methods current study explored TRPV1 functions noxious sensory input mice cold stress model. It remains unknown whether electroacupuncture (EA) attenuates or affects pathway. Results We show increases mechanical thermal (day 7: mechanical: 1.69 ± 0.41 g; thermal: 4.68 0.56 s), EA Trpv1 deletion counter this increase. reduced stress-induced increase inflammatory mediators TRPV1-related molecules hypothalamus, periaqueductal gray (PAG), cerebellum mice. Conclusions Our results imply has an analgesic effect downregulation. provide novel evidence these modulate signaling pathway suggest new therapeutic targets for